Which Statement by a Client Taking Estrogen/progesterone Combination Hormone Replacement

Which statement by a client taking estrogen/progesterone combination hormone replacement therapy (HRT) requires immediate intervention by the nurse?

A) I have gained 6 pounds since I began taking this medication 3 months ago."
B) Sexual intercourse is still slightly uncomfortable,even though I have been on the medication for 2 months."
C) I got nauseated and had right shoulder pain after I ate fried fish last night."
D) My ankles are swollen when I go to bed at night."