The nurse is preparing to administer a sublingual nitroglycerin tablet.With regard to the first-pass effect,the nurse understands that:

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Drugs given sublingually bypass the first-pass effect, as they are absorbed directly into the bloodstream through the sublingual mucosa, rather than being metabolized in the liver before reaching systemic circulation. Therefore, this route of administration is often preferred for drugs that are extensively metabolized in the liver, such as nitroglycerin, in order to increase their bioavailability and effectiveness.

The Nurse Is Preparing to Administer a Sublingual Nitroglycerin Tablet