A Client Receiving Antineoplastic Agents in the Treatment of Lung

A client receiving antineoplastic agents in the treatment of lung cancer has been told that treatment options are limited.The nurse explains that lung cancer has a decreased sensitivity to antineoplastic agents because lung cancer cells:

A) have a very erratic cell cycle,and there is little difference between the number of replicating and resting cells.
B) grow for a long time before detection and are therefore less sensitive to antineoplastic agents.
C) grow in a high-oxygen environment and are therefore not very sensitive to antineoplastic agents.
D) have a low growth fraction,so there is little difference between the number of replicating and resting cells.