A client reports no improvement after 5 days of therapy with tetracycline.The nurse suspects drug resistance and knows that drug resistance can develop in which ways?
Select all that apply.

Question

Quizplus · Accepted Answer

Drug resistance can develop through various mechanisms: A) Bacteria can develop mechanisms to prevent the accumulation of a drug inside the cell, making the drug less effective. B) The use of broad-spectrum antibiotics can lead to resistance by eliminating sensitive bacteria and allowing resistant bacteria to proliferate. D) Bacteria can acquire genes that enable them to produce enzymes that degrade or modify the antibiotic, rendering it ineffective. E) Mutation in bacterial genes can alter the target site of the antibiotic, preventing it from binding effectively and inhibiting the bacteria. Pairing a bacteriostatic agent with a bactericidal agent (C) is not a recognized mechanism of developing drug resistance; instead, it's a consideration in antibiotic therapy to avoid antagonistic effects.

A Client Reports No Improvement After 5 Days of Therapy