A client with myasthenia gravis is demonstrating weakness 4 hours after taking the last dose of pyridostigmine (Mestinon).What may be the cause of the client's weakness?
Select all that apply.

Question

Quizplus · Accepted Answer

Myasthenia gravis is a chronic autoimmune disorder that affects the transmission of nerve impulses to muscles, leading to muscle weakness and fatigue. Pyridostigmine is a medication that helps improve muscle strength by increasing the amount of acetylcholine available at the neuromuscular junction. If the client is demonstrating weakness 4 hours after taking the last dose of pyridostigmine, it could be due to a higher dose being needed (choice A) or the development of drug resistance (choice B). A lower dose of medication (choice C) or rejection by the autonomic nervous system (choice D) are unlikely causes. Atropine is sometimes given to counteract the side effects of pyridostigmine, but it would not necessarily address the client's weakness in this case.

A Client with Myasthenia Gravis Is Demonstrating Weakness 4 Hours