A mutation in the gene encoding the integrase enzyme renders the protein non-functional.How would this affect-the HIV infection cycle?
A)The gp120 glycoprotein would not be able to bind the CCR5 receptor.
B)Reverse transcription would not be possible.
C)The viral DNA would not be able to integrate the viral genome into a chromosome.
D)Cutting and assembling the capsid would be halted.

Question

Quizplus · Accepted Answer

Integrase is responsible for integrating the viral DNA into the host cell chromosome. A mutation in the gene encoding the integrase enzyme would render the enzyme non-functional, which would prevent the viral DNA from integrating into the host cell chromosome. This would stop the HIV infection cycle as the virus would not be able to replicate and produce new viral particles.

A Mutation in the Gene Encoding the Integrase Enzyme Renders