Many genes in the human genome are no longer expressed because mutations have introduced stop codons within the coding sequence or transposons have disrupted gene function.These genes are now considered

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Genes that are no longer expressed due to mutations or disruptions are considered pseudogenes. Orthologs refer to genes in different species that evolved from a common ancestral gene, paralogs refer to genes that arose through gene duplication within a genome, and homologues refer to genes that share a common evolutionary origin.

Many Genes in the Human Genome Are No Longer Expressed