The mutation responsible for Huntington's disease is a
A)missense mutation.
B)nonsense mutation.
C)frameshift mutation.
D)triplet repeat expansion mutation.

Question

Quizplus · Accepted Answer

The mutation responsible for Huntington's disease is a triplet repeat expansion mutation, where a repeated sequence of three nucleotides (CAG) in the DNA is expanded, leading to a change in the protein produced by the gene. This results in the accumulation of abnormal proteins in the brain, leading to the symptoms of the disease. Missense, nonsense, and frameshift mutations involve different types of changes in the DNA sequence that can also lead to changes in protein structure and function, but are not specific to Huntington's disease.

The Mutation Responsible for Huntington's Disease Is a