Xeroderma pigmentosum (XP)is a rare autosomal recessive disorder.Patients with XP exhibit a cellular hypersensitivity to ultraviolet (UV)radiation,a high incidence of skin cancer and premature aging.Based on these clinical characteristics,what is the most likely cause for this disease?

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Patients with XP exhibit a cellular hypersensitivity to ultraviolet (UV) radiation, a high incidence of skin cancer and premature aging. These clinical characteristics suggest that there is a defect in DNA repair, specifically in the nucleotide excision repair pathway, which is responsible for removing DNA damage caused by UV radiation.

Xeroderma Pigmentosum (XP)is a Rare Autosomal Recessive Disorder