In sickle cell anemia,the defective hemoglobin differs from the normal hemoglobin by
A)the color of the pigment.
B)the size of the molecule.
C)a single amino acid substitution.
D)the total number of amino acids.
E)the type of blood cell it is found in.

Question

Quizplus · Accepted Answer

Sickle cell anemia is caused by a single amino acid substitution in the hemoglobin protein, where valine is substituted for glutamic acid. This results in a change in the shape of the red blood cells, causing them to become rigid and take on a sickle shape, causing various complications. The other options mentioned are not relevant to the difference between normal and defective hemoglobin in sickle cell anemia.

In Sickle Cell Anemia,the Defective Hemoglobin Differs from the Normal