A deletion of a particular stretch of chromosome 15 can cause either Prader-Willi syndrome or Angelman syndrome,depending on
A)the parental origin of the normal and deleted chromosome.
B)whether or not the region is methylated properly.
C)whether a translocation event has occurred.
D)whether a nondisjunction event has occurred.

Question

Quizplus · Accepted Answer

Prader-Willi syndrome and Angelman syndrome are caused by the deletion of the same stretch of chromosome 15, but the syndrome that is expressed is dependent on the parental origin of the normal and deleted chromosome. If the deletion occurs on the paternal chromosome 15, it will result in Prader-Willi syndrome. If the deletion occurs on the maternal chromosome 15, it will result in Angelman syndrome.

A Deletion of a Particular Stretch of Chromosome 15 Can