What would you expect to happen if the anaphase-promoting complex/cyclosome (APC/C)failed to ubiquitinate securin?
A)The cohesin complex will be destroyed,and the cell will remain in metaphase.
B)The cohesin complex will persist,preventing the cell from entering anaphase.
C)Separase will be marked for degradation by securin,preventing the cell from entering anaphase.
D)Securin will remain intact and therefore will degrade cohesin,allowing the cell to enter anaphase.

Question

Quizplus · Accepted Answer

When securin is not ubiquitinated by APC/C, it cannot be degraded and therefore cannot be released from separase. Thus, separase cannot cleave the cohesin complex and the sister chromatids will remain attached, preventing the cell from entering anaphase. This results in a delay in cell division or arrest in metaphase. Therefore, the correct answer is B.

What Would You Expect to Happen If the Anaphase-Promoting Complex/cyclosome