Glycogen Storage Disease Type II (GSD II),also known as Pompe disease,is a metabolic disorder that leads to the accumulation of glycogen in muscles and neurons throughout the body.It is caused by a defect in an enzyme that is normally housed with other enzymes that are involved in breaking down large macromolecules.What organelle is most likely affected by this disease?

Question

Quizplus · Accepted Answer

GSD II is caused by a defect in the enzyme acid alpha-glucosidase (GAA), which normally breaks down glycogen in lysosomes. Therefore, lysosomes are the organelle most likely affected by this disease.

Glycogen Storage Disease Type II (GSD II),also Known as Pompe