When the Nurse Is Interviewing a Preadolescent Girl, Which Opening

When the nurse is interviewing a preadolescent girl, which opening question would be least threatening?

A) "Do you have any questions about growing up?"
B) "What has your mother told you about growing up?"
C) "When did you notice that your body was changing?"
D) "I remember being very scared when I got my period. How do you think you'll feel?"