______ of tau aggregates leads to formation of paired helical fibrils that associate further to produce insoluble aggregates.

Question

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Hyperphosphorylation of tau is a key event in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. This hyperphosphorylation leads to the formation of paired helical fibrils (PHFs) that further associate to produce insoluble aggregates.

______ of Tau Aggregates Leads to Formation of Paired Helical