For gene expression to occur,histones must be modified so that they loosen their grip on the DNA.This is accomplished by:

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Histone acetylation is the process by which acetyl groups are added to histone proteins, which results in the loosening of their grip on DNA. This allows for easier access of transcription factors and RNA polymerase to the DNA, resulting in increased gene expression. Histone deacetylation has the opposite effect, tightening the grip of the histones on the DNA and resulting in decreased gene expression. Phosphorylation and dephosphorylation of histones may also play a role in gene expression, but they do not directly result in the loosening of histone grip on DNA.

For Gene Expression to Occur,histones Must Be Modified So That