The Nurse Is Researching the Pathophysiology and Etiology of Major

The nurse is researching the pathophysiology and etiology of major depressive disorder. What will the nurse learn is true regarding neurological structure alterations and the development of major depressive disorder? Select all that apply.

A) An increase in the central nervous system (CNS) volume is associated with major depressive disorder.
B) Excessive levels of serotonin and norepinephrine have been associated with major depressive disorder.
C) Impairments to cerebral structural plasticity and neuronal cellular resilience have been noted with major depressive disorder.
D) An increase in the numbers and sizes of glia and neurons in some areas of the brain have been noted with major depressive disorder.
E) Dysfunction of cerebral blood flow and glucose metabolism in some areas of the brain has been noted with major depressive disorder.