What is (are)the missing reagent(s)in the reaction below?

Question

Quizplus · Accepted Answer

The reaction is a typical nucleophilic substitution reaction on a primary alkyl halide. The missing reagent should be a nucleophile that can replace the leaving group (iodide) in the reaction. Option A (NHS and H2O) is not a suitable nucleophile for this type of reaction. Option B (HCN) is a weak nucleophile and not very effective in displacing the leaving group. Option D (NaNH2) is a strong base but not a good nucleophile. Option C (NaCN and NHSO2Cl) is a good choice because NaCN is a strong nucleophile and NHSO2Cl can help to activate the electrophile (alkyl halide) by converting it to a sulfonyl chloride.

What Is (Are)the Missing Reagent(s)in the Reaction Below