Fill in the Blanks with Single Words

Fill in the blanks with single words.
In some diseases the problem is the loss of some function and a type of ____1_____ therapy is used to supplement the resulting deficiency. It may be a deficiency in some normal aspect of the ____2_____, such as deafness, a deficiency of organs or ____3____ , or a deficiency of molecules (which might be at the level of ____4_____ , ____5_____ , or downstream factors). Sometimes, however, disease is not due to a deficiency; instead, the problem is that there is some positively _____6_____ effect produced at some level (at the level of the phenotype, ____3_____ or ____4______ ), that cannot be supplemented. Here treatment is possible by seeking to eliminate, correct or ____ 7_____ the agent causing the positively _____6_____ effect. The treatment might seek to kill dangerous _____3____ , for example, or to ____7_____ a _____6_____ _____4_____ or a _____7_____ _____6_____. In the latter case, the treatment might often be to use some kind of _____8_____ , such as a conventional ____9_____ molecule ____8_____ that usually works by binding to a cleft in the _____6_____ _____5_____ and thereby ____7____ its ____6____ effect. A third class of disease treatment seeks to use a ____8____ in order to alter a person's ______10_______ to the disease, or to alter exposure to some _____11_____ factor.