HLA associations with autoimmune disorders are among the very strongest of associations between genetic variants and disease, but have rarely been mapped to the amino acid level. An exception is the HLA association with rheumatoid arthritis. What is known about this association, and how did detailed knowledge of how HLA proteins function help to identify the amino acids implicated in the association?

Question

Quizplus · Accepted Answer

The Answer of HLA associations with autoimmune disorders are among the very strongest of associations between genetic variants and disease, but have rarely been mapped to the amino acid level. An exception is the HLA association with rheumatoid arthritis. What is known about this association, and how did detailed knowledge of how HLA proteins function help to identify the amino acids implicated in the association?

HLA Associations with Autoimmune Disorders Are Among the Very Strongest