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The Pathogenesis Of α\alpha 1-Antitrypsin Deficiency Due to the Common Missense Mutants PI*S and Missense

Question 45

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The pathogenesis of α\alpha 1-antitrypsin deficiency due to the common missense mutants PI*S and PI*Z is due to a failure in protein processing and secretion, and to aberrant protein aggregation. Explain how.

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blured image1-antitrypsin is a plasma pro...

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