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For Some Single Gene Disorders, Some Members of a Family

Question 20

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For some single gene disorders, some members of a family who have the same genetic variants at the disease locus as strongly affected family members either show a much milder phenotype or no disease symptoms. List five explanations for why there can be a lack of penetrance or variable expressivity of a single gene disorder.

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1) Epigenetic regulation. For example, l...

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