Mutations in BRCA1 and BRCA2 ____.
A)lead to increased telomerase activity
B)give rise to neoplasms in the breast
C)cause cells to become senescent
D)arrest cell cycle progression
E)cause cells to undergo apoptosis

Question

Quizplus · Accepted Answer

Mutations in BRCA1 and BRCA2 are associated with an increased risk of developing neoplasms, especially in the breast and ovaries. They are involved in DNA repair and their loss of function can lead to genomic instability and the accumulation of mutations that can contribute to cancer development. There is no evidence that these mutations lead to increased telomerase activity, cause cells to become senescent, arrest cell cycle progression or cause cells to undergo apoptosis in the absence of additional factors.