In treating AIDS, reverse transcriptase inhibitors are often combined with protease inhibitors that:

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Protease inhibitors work by blocking the activity of HIV protease enzyme, which is needed to produce infectious viral particles. By combining protease inhibitors with reverse transcriptase inhibitors, multiple stages of the HIV life cycle are targeted, making it harder for the virus to replicate and spread. This combination therapy has been shown to be effective in treating HIV/AIDS.

In Treating AIDS, Reverse Transcriptase Inhibitors Are Often Combined with Protease