A Patient Has Severe Emphysema That Has Extensively Damaged the Alveoli

A patient has severe emphysema that has extensively damaged the alveoli and reduced the surface of the respiratory membrane.Despite receiving oxygen therapy,she still has a tremendous urge to take a breath,that is,she doesn't feel as if she is getting enough air.This is because

A) the oxygen stimulates the respiratory rate to increase even more.
B) oxygen increases the stimulation of the carotid and aortic bodies.
C) oxygen stimulates the vasomotor center,which results in vasoconstriction of blood vessels.
D) even though she is receiving enough oxygen,carbon dioxide and hydrogen ions are accumulating in her blood and stimulating the respiratory center.
E) pH increased in her blood,and over stimulated her respiratory center.