Which of These Statements Concerning Membrane-Bound Receptors Is True

Which of these statements concerning membrane-bound receptors is true?

A) Chemical signals that are large,water-soluble molecules normally bind to membrane-bound receptors.
B) Membrane-bound receptors increase protein synthesis in the cell.
C) Membrane-bound receptors are sometimes located in the nucleus of the cell.
D) When intercellular chemical signals bind to membrane-bound receptors,the response usually requires several hours.
E) Membrane-bound receptors must be able to rapidly diffuse through the cell membrane.