A Patient with Sickle Cell Disease Tells the Nurse That

A patient with sickle cell disease tells the nurse that she knows when the disease is going to flare because she has pain in her arms and legs.Which explanation would the nurse provide?

A) "The shape of your blood cells blocks the small capillaries in your arms and legs."
B) "The pain is really due to your history of malaria along with having sickle cell anemia."
C) "Your spleen is destroying all the malformed red blood cells,which makes you anemic and causes arm and leg pain."
D) "The chronic blood loss associated with sickle cell anemia causes pain in the arms and legs."