Which neurotransmitters in the brain are most often acted upon by the use of antidepressant medications?

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The neurotransmitters most often acted upon by antidepressant medications are serotonin and norepinephrine. Selective serotonin reuptake inhibitors (SSRIs) primarily increase the levels of serotonin in the brain, while serotonin-norepinephrine reuptake inhibitors (SNRIs) increase levels of both serotonin and norepinephrine. Other types of antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs), also act on these two neurotransmitters, as well as others.

Which Neurotransmitters in the Brain Are Most Often Acted Upon