Canine phosphofructokinase PFK) deficiency afflicts springer spaniels, affecting an estimated 10% of the breed. PFK is the glycolytic enzyme that phosphorylates fructose- 1- phosphate and catalyzes the committed step in glycolysis. Given its critical role in glycolysis, one implication of the genetic defect resulting in PFK deficiency in dogs is

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As PFK is critical in glycolysis, its deficiency leads to impaired energy metabolism and muscle function, resulting in exercise intolerance in affected dogs.

Canine Phosphofructokinase PFK) Deficiency Afflicts Springer Spaniels, Affecting an Estimated