What would happen if an enzyme inhibitor for the enzyme phosphodiesterase PDE) was applied to a vertebrate eye?

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Quizplus · Accepted Answer

Phosphodiesterase (PDE) is an enzyme that breaks down cyclic guanosine monophosphate (cGMP) in the photoreceptor cells of the retina. cGMP-gated sodium channels in the outer segment of the photoreceptor cells are activated by light, leading to depolarization and the release of neurotransmitter glutamate at the synapses with bipolar cells. Inactivation of PDE by an inhibitor would prevent the breakdown of cGMP and keep the cGMP-gated sodium channels open, resulting in continuous glutamate release and the inability of the brain to detect light absorbed by the rod cells. This would lead to loss of vision in dim light conditions, which is a symptom of the human condition known as retinitis pigmentosa.

What Would Happen If an Enzyme Inhibitor for the Enzyme