Tetrodotoxin blocks voltage- gated sodium channels and ouabain blocks sodium- potassium pumps. If you added both tetrodotoxin and ouabain to a solution containing neural tissue, what responses would you expect?
A) no effect; the substances counteract each other
B) slow decrease of resting potential and action potential amplitudes
C) immediate loss of action potential with gradual loss of resting potential
D) immediate loss of resting potential

Question

Quizplus · Accepted Answer

Tetrodotoxin blocks voltage-gated sodium channels, preventing action potentials, while ouabain blocks sodium-potassium pumps, leading to a gradual loss of resting potential. Therefore, the immediate loss of action potential with a gradual loss of resting potential is expected.

Tetrodotoxin Blocks Voltage- Gated Sodium Channels and Ouabain Blocks Sodium-