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Use the Following Information When Answering the Corresponding Questions)

Question 26

Multiple Choice

Use the following information when answering the corresponding questions) .
It has been shown that there are two distinct variants of the HIV virus Bleul et al. 1997. The HIV coreceptors CXCR4 and CCR differentially regulated on human T- lymphocytes. Proceedings of the National Academy of Science 94:1925- 30) . One virus preferentially infects macrophages and is called M- tropic. The other preferentially infects T cells and is called T- tropic. The M- tropic viruses use CCR5 and CD4 as coreceptors, and the T- tropic viruses use CXCR4 and CD4 as coreceptors. The
M- tropic viruses are found early in HIV infections; the T- tropic viruses are found late in infections, when AIDS symptoms are prevalent. T- tropic viruses are associated with a drastic decrease in T cells. Macrophages go to the site of wounds, where they are used to fight infections. T cells circulate in the body and fight infections at many sites.
-What would the result be if a drug that blocks the action of RNA polymerase was introduced into a virus- infected organism?


A) The newly formed virions virus particles) would be unable to leave the host cell.
B) The viral proteins would not be made, and the virus would not be able to reproduce.
C) Viral proteins and viral DNA particles would not be able to assemble.
D) The virus would not be able to enter new host cells.

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