The proteome is all the proteins produced by an organism. The genome is the totality of all genes of an organism. If the proteome is much larger than the genome, which of the following statements would be accurate?

Question

Quizplus · Accepted Answer

If the proteome is much larger than the genome, it means that a single gene must code for more than one protein, which is achieved through alternate splicing or post-translational modifications. Therefore, option D is the most accurate statement. Option A is not true because proteins are made up of monomeric subunits called amino acids, which are not directly related to the number of monomeric subunits in genes. Option B is also not true because noncoding DNA does not directly determine the proteome, but it can regulate gene expression. Option C is incorrect because the one gene-one enzyme hypothesis has been revised to the one gene-one polypeptide hypothesis, which acknowledges that some genes can code for multiple polypeptides or proteins.

The Proteome Is All the Proteins Produced by an Organism