Signals from the extracellular matrix to the cytoskeleton may be transmitted by

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Integrins are a family of transmembrane receptors that connect the extracellular matrix to the cytoskeleton. They transmit signals bidirectionally, meaning they can send signals into the cell (outside-in signaling) or receive signals from the cell (inside-out signaling). Integrins bind to various components of the extracellular matrix, such as collagen and fibronectin, and are involved in processes such as cell adhesion, migration, and differentiation. Proteoglycans and the middle lamella are not directly involved in signal transmission between the extracellular matrix and cytoskeleton.

Signals from the Extracellular Matrix to the Cytoskeleton May Be