The antimicrobial drugs with the broadest spectrum of activity are

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Tetracyclines have a broad spectrum of activity, covering both gram-positive and gram-negative bacteria, as well as many atypical bacteria and even some protozoa. They are often used as a first-line treatment for a wide range of infections. Chloramphenicol and aminoglycosides also have a broad spectrum of activity, but are more limited in their use due to potential toxicity. Penicillin G and macrolides have more restricted spectra of activity.

The Antimicrobial Drugs with the Broadest Spectrum of Activity Are