Muscle cells from normal and obese type 2 diabetic patients were analyzed for plasma membrane lipid content.Which of the following would likely be elevated in the diabetic patient?
A) IR
B) IRS1
C) IP3
D) DAG

Question

Quizplus · Accepted Answer

Diacylglycerol (DAG) tends to be increased in insulin-resistant individuals, including those with obesity and type 2 diabetes. DAG impairs insulin signaling by activating protein kinase C, which in turn impairs insulin signaling pathways, leading to decreased glucose uptake and utilization by cells. IR (insulin receptor), IRS1 (insulin receptor substrate 1), and IP3 (inositol triphosphate) are not directly related to membrane lipid content and are unlikely to be elevated in the diabetic patient.

Muscle Cells from Normal and Obese Type 2 Diabetic Patients