Orlistat and olestra can both lead to undigested lipids in the colon, yet they do so by contrasting mechanisms. Orlistat __________, whereas olestra _.
A) inhibits pancreatic lipase; activates PPAR$\gamma$
B) inhibits pancreatic lipase; is a fat substitute that is not a substrate for pancreatic lipase
C) is a fat substitute that is not a substrate for pancreatic lipase; inhibits pancreatic lipase
D) activates PPAR$\gamma$; inhibits pancreatic lipase

Question

Quizplus · Accepted Answer

Orlistat inhibits pancreatic lipase, an enzyme responsible for breaking down dietary fat into absorbable fatty acids. As a result, undigested fat passes through the digestive system, leading to oily stools and other gastrointestinal issues. Olestra, on the other hand, is a fat substitute that is not a substrate for pancreatic lipase. It passes through the digestive system without being absorbed, taking with it some of the fat consumed in a meal. This can lead to undigested lipids in the colon and potentially cause gastrointestinal discomfort.

Orlistat and Olestra Can Both Lead to Undigested Lipids in the Colon