A mutation in the gene encoding which of the following enzymes would affect the synthesis of both AMP and GMP?
A) adenylosuccinate synthetase
B) PRPP synthetase
C) IMP dehydrogenase
D) GMP synthase

Question

Quizplus · Accepted Answer

PRPP synthetase is the enzyme that catalyzes the first step in the de novo synthesis of both AMP and GMP. Therefore, a mutation in the gene encoding PRPP synthetase would affect the synthesis of both AMP and GMP. Adenylosuccinate synthetase catalyzes the synthesis of AMP, IMP dehydrogenase catalyzes the conversion of IMP to GMP, and GMP synthase catalyzes the synthesis of GMP. Mutations in the genes coding for any of these enzymes would affect the synthesis of only one of the two nucleotides, either AMP or GMP, but not both.

A Mutation in the Gene Encoding Which of the Following