Tyr122 is important in the mechanism of the E.coli ribonucleotide reductase.The function of this amino acid in the mechanism is to
A) carry out a nucleophilic attack on the substrate.
B) coordinate water in the active site.
C) generate the Cys439 radical species.
D) hydrogen-bond to the phosphates of the substrate.

Question

Quizplus · Accepted Answer

Tyr122 acts as a proton donor in the mechanism of generating the Cys439 radical species that initiates the reduction of ribonucleotides to deoxyribonucleotides.

Tyr122 Is Important in the Mechanism of the E