In severe combined immunodeficiency disease (SCID),ribonucleotide reductase activity is __________ because of an overabundance of __________.

Question

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In severe combined immunodeficiency disease (SCID), ribonucleotide reductase activity is inhibited because of an overabundance of dATP. The accumulation of dATP leads to feedback inhibition of ribonucleotide reductase, which is necessary for DNA synthesis and cell proliferation. This inhibition specifically affects the production of deoxyribonucleotides, leading to impaired lymphocyte proliferation and immune function.

In Severe Combined Immunodeficiency Disease (SCID),ribonucleotide Reductase Activity Is __________