Reduction in dTMP biosynthesis is NOT dependent upon __________.
A) methotrexate
B) aminopterin
C) raltitrexed
D) dihydrofolate

Question

Quizplus · Accepted Answer

Reduction in dTMP biosynthesis is dependent on dihydrofolate, which is a precursor for the synthesis of tetrahydrofolate. Methotrexate, aminopterin and raltitrexed are all inhibitors of dihydrofolate reductase, which is required for the conversion of dihydrofolate to tetrahydrofolate. Therefore, these drugs can reduce dTMP biosynthesis by inhibiting the production of tetrahydrofolate, which is necessary for the synthesis of thymidylate.

Reduction in DTMP Biosynthesis Is NOT Dependent Upon __________