Which two enzymes in the citrate cycle are affected by arsenic poisoning?
A) pyruvate dehydrogenase and succinate dehydrogenase
B) pyruvate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase
C) malate dehydrogenase and succinate dehydrogenase
D) malate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase

Question

Quizplus · Accepted Answer

Arsenic poisoning specifically disrupts the activity of enzymes that contain lipoic acid, an essential cofactor. Both pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (also known as F1F1F1S1αF1F1F10-ketoglutarate dehydrogenase) contain lipoic acid and are affected by arsenic poisoning. The other enzymes listed do not contain lipoic acid and are not affected by arsenic poisoning.

Which Two Enzymes in the Citrate Cycle Are Affected by Arsenic