Arsenite affects the lipoamide coenzymes of the pyruvate dehydrogenase reaction by
A) acting as a competitive inhibitor.
B) covalently modifying the coenzyme.
C) being a noncompetitive inhibitor.
D) modifying the coenzyme through electrostatic interactions.

Question

Quizplus · Accepted Answer

Arsenite covalently modifies the lipoamide coenzymes of the pyruvate dehydrogenase reaction by forming an irreversible bond with the sulfhydryl groups of the coenzyme. This results in the inactivation of the enzyme and disruption of its function.

Arsenite Affects the Lipoamide Coenzymes of the Pyruvate Dehydrogenase Reaction