The $\Delta$G$\degree$ ^' of the conversion from malate to oxaloacetate in the last reaction of the citrate cycle is very large, indicating this reaction is not thermodynamically favorable. Propose an explanation for how this reaction can proceed in the forward direction despite the very positive $\Delta$G$\degree$^' value.

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The Answer of The $\Delta$G$\degree$ ^' of the conversion from malate to oxaloacetate in the last reaction of the citrate cycle is very large, indicating this reaction is not thermodynamically favorable. Propose an explanation for how this reaction can proceed in the forward direction despite the very positive $\Delta$G$\degree$^' value.

The Δ\DeltaΔ G °\degree° ' of the Conversion from Malate to Oxaloacetate in Malate

The $\Delta$ G $\degree$ ^' of the Conversion from Malate to Oxaloacetate in Malate