What advantage is there to phosphoglycerate kinase having an open and closed configuration?
A) It allows water to be trapped in the active site along with the substrate.
B) It forces covalent binding of the substrate to the enzyme active site.
C) The induced-fit mechanism maximizes accessibility of active site without sacrificing hydrophobic environment.
D) Changing of the configuration of the enzyme makes the reaction exergonic.

Question

Quizplus · Accepted Answer

The induced-fit mechanism allows the active site of phosphoglycerate kinase to maximize accessibility to the substrate without sacrificing the hydrophobic environment needed for catalysis. The open and closed configuration allows the enzyme to accommodate different substrates and undergo the necessary conformational changes for efficient catalysis. A and B are incorrect because there is no advantage to trapping water or forcing covalent binding in the active site. D is incorrect because changing the configuration of the enzyme does not necessarily make the reaction exergonic.

What Advantage Is There to Phosphoglycerate Kinase Having an Open