Which of the following metabolic conversions is considered to be the major control point of glycolysis?
A) fructose-1,6-bisphosphate $\rightarrow$dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
B) 1,3-Bisphosphoglycerate + ADP $\rightarrow$3-Phosphoglycerate + ATP
C) 2-phosphoglyerate $\rightarrow$phosphoenolpyruvate
D) fructose-6-phosphate $\rightarrow$fructose-1,6-bisphosphate

Question

Quizplus · Accepted Answer

The conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, catalyzed by the enzyme phosphofructokinase (PFK), is considered to be the major control point of glycolysis. PFK is regulated by a number of factors, including ATP, ADP, and citrate, making it sensitive to the energy and metabolic needs of the cell. Therefore, the regulation of PFK activity and the fructose-6-phosphate to fructose-1,6-bisphosphate conversion is critical in controlling the flux of glucose through glycolysis.

Which of the Following Metabolic Conversions Is Considered to Be →\rightarrow→

Which of the Following Metabolic Conversions Is Considered to Be $\rightarrow$