What effect do elevated levels of ATP have on glycolysis?
A) decrease the affinity of PFK-1 for fructose-6-P and slow rate of the pathway
B) increase the affinity of PFK-1 for fructose-6-P and increase the rate of the pathway
C) increase the concentration of PFK-1 in the R-state
D) increase the concentration of glucose entering glycolysis

Question

Quizplus · Accepted Answer

Elevated levels of ATP indicate that the energy needs of the cell are met, so there is no need to continue producing ATP through glycolysis. In response, the cell reduces the rate of the pathway by decreasing the affinity of PFK-1 for fructose-6-P. This is because the enzyme is allosterically inhibited by ATP, and as ATP levels rise, it becomes more tightly bound to PFK-1, slowing down the rate of glycolysis.

What Effect Do Elevated Levels of ATP Have on Glycolysis