If GRB2 were truncated so that the N-terminal domain was missing,the truncated protein would be unable to bind the
A) phosphorylated Tyr of the SOS protein.
B) phosphorylated Tyr of the RTK substrate.
C) proline-rich sequence of the SOS protein.
D) protein-rich sequence of the RTK substrate.

Question

Quizplus · Accepted Answer

The N-terminal domain of GRB2 contains the SH3 domain, which is responsible for binding to the proline-rich sequences of the SOS protein. Without this domain, GRB2 cannot bind to SOS.

If GRB2 Were Truncated So That the N-Terminal Domain Was