Consider a mutant cell that does not form DISC on TNF signaling. Which of the following would occur in this mutant cell if exposed to TNF-$\alpha$?
A) Caspase 3 would be activated.
B) TNF-$\alpha$would bind to the TNF receptor.
C) Caspase 8 would be activated.
D) The cell would undergo apoptosis.

Question

Quizplus · Accepted Answer

If the mutant cell cannot form DISC on TNF signaling, it means it cannot activate caspase 8, which is a crucial initiator caspase in the TNF-mediated apoptosis pathway. Therefore, the answer choices that involve caspase 3 or apoptosis can be eliminated. TNF-F1F1F1S1F1F1F10 can still bind to the TNF receptor on the cell surface, but without DISC formation, the downstream signaling pathway leading to apoptosis cannot be initiated. Therefore, the correct answer is B.

Consider a Mutant Cell That Does Not Form DISC on TNF