Removal of which metal ion would likely alter the structure of the GR DNA-binding domain and preclude it from binding to DNA? A) Zn²⁺ B) Mg²⁺ C) Ca²⁺ D) Fe²⁺

Question

Quizplus · Accepted Answer

The GR DNA-binding domain is a zinc finger motif, which means that it contains zinc ions that are necessary for its structure and function. Removal of the zinc ion (Zn2+) would likely alter the structure of the zinc finger and preclude it from binding to DNA, as the zinc ion plays a critical role in stabilizing the structure of the motif. Magnesium (Mg2+), calcium (Ca2+), and iron (Fe2+) ions do not have the same effect on the structure of the zinc finger motif, as they do not coordinate with the protein in the same way as zinc ions.

Removal of Which Metal Ion Would Likely Alter the Structure